Sulfuric Acid → HCID 86723398, compound

Participants

Reaction Steps

Following the procedure for Example 12, 2-(diethoxymethyl)-5-fluoro-N-tritylpyridin-4-amine (457 mg, 1 mmol), conc H2SO4 (0.2 mL), CH3CN (5 mL) and H2O (5 mL) gave 4-amino-5-fluoropicolinaldehyde (126 mg, 87%) as a white solid: mp 133-135° C.; 1H NMR (400 MHz, CDCl3) δ 9.90 (s, 1H), 8.34 (d, J=2.7 Hz, 1H), 7.36 (d, J=7.5 Hz, 1H), 4.47 (br s, 2H); 19F NMR (376 MHz, CDCl3) δ −144.44; HRMS-ESI (P/z) [M+H]+ calcd for C6H5FN2O, 140.0386. found, 140.0384.

Provenance & Evidence