1,3-Dichloro-5,5-dimethylhydantoin → HCID 86723402, compound

Participants

Reaction Steps

Using the procedure for Example 15, 4-amino-6-(tert-butyl)-5-fluoropicolinaldehyde (0.5 g, 2.55 mol), 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione (0.276 g, 1.401 mol) CH3CN (26 mL) gave 4-amino-6-(tert-butyl)-3-chloro-5-fluoropicolinaldehyde (423 mg, 70.5%) as a yellow oil: 1H NMR (400 MHz, CDCl3) δ 10.01 (s, 1H), 4.76 (d, J=7.2 Hz, 3H), 1.42 (d, J=1.6 Hz, 9H); 19F NMR (376 MHz, CDCl3) δ −132.69; 13C NMR (101 MHz, CDCl3) δ 191.27, 152.89, 149.20, 146.51, 141.75, 139.93, 36.97, 28.39; EIMS m/z 230.

Provenance & Evidence