1,3-Dichloro-5,5-dimethylhydantoin → HCID 86723405, compound

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Reaction Steps

Using the procedure for Example 15, 4-amino-5-fluoro-6-(4-fluorobenzyl)-picolinaldehyde (0.5 g, 2.014 mmol), 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione (0.218 g, 1.108 mmol) and CH3CN (20 mL) gave 4-amino-3-chloro-5-fluoro-6-(4-fluorobenzyl)picolinaldehyde (428 mg, 73.7%) as an orange solid: mp 109-111° C.; 1H NMR (400 MHz, CDCl3) δ 10.08 (s, 1H), 7.28 (m, 3H), 6.97 (m, 2H), 4.84 (s, 2H), 4.14 (d, J=3.1 Hz, 2H); 19F NMR (376 MHz, CDCl3) δ −116.40, −139.04; 13C NMR (101 MHz, CDCl3) δ 190.27, 162.96, 160.53, 148.18, 145.80, 145.67, 145.61, 143.17, 139.85, 139.72, 133.24, 130.38, 130.31, 115.47, 115.26, 37.10, 37.08; EIMS m/z 282.

Provenance & Evidence