1,3-Dichloro-5,5-dimethylhydantoin → HCID 86723406, compound

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Reaction Steps

Using the procedure for Example 15, 4-amino-3-fluoro-6′-(trifluoromethyl)-[2,3′-bipyridine]-6-carbaldehyde (200 mg, 0.701 mmol), 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione (76 mg, 0.386 mmol) and CH3CN (7 mL) gave 4-amino-5-chloro-3-fluoro-6′-(trifluoromethyl)-[2,3′-bipyridine]-6-carbaldehyde (182 mg, 69.8%) as a yellow solid: mp 147-149° C.; 1H NMR (400 MHz, CDCl3) δ 10.14 (s, 1H), 9.34 (d, J=2.0 Hz, 1H), 8.54 (m, 1H), 7.84 (m, 1H), 5.13 (s, 2H); 19F NMR (376 MHz, CDCl3) δ −68.02, −137.62.

Provenance & Evidence