HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Fluoro-6-nitrophenyl)propanoic acid → 5-Fluoro-3,4-dihydroquinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Fluoro-6-nitrophenyl)propanoic acid | HCID 15691443 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Fluoro-3,4-dihydroquinolin-2(1H)-one | HCID 22736942 | 99.5% |
Reaction Steps
The suspension of 3-(2-fluoro-6-nitrophenyl)propanoic acid (6.0 g, 28 mmol) and 10% Pd-C (300 mg) in MeOH was hydrogenated under H2 (4 atm) for 3 h. After filtration, the filtrate was concentrated in vacuo to afford 5-Fluoro-3,4-dihydroquinolin-2(1H)-one (4.6 g) as a slightly brown solid. This crude product was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713490B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-b40c29e6a78948fdbef5b0ea2d4d3f58 |
| Source note | uspto-grants-2004_03 |