Sulfuric Acid → HCID 178459009, compound

Participants

Reaction Conditions

Reaction Steps

The compound of Example 1 (123 mg) was dissolved in isopropanol (2 mL), and concentrated sulfuric acid (41 mg) was added thereto. The mixture was heated at 140° C. for one hour and at 160° C. for 2 hours by means of a microwave reaction apparatus. The reaction mixture was basified with a 10% aqueous solution of sodium hydroxide and extracted with chloroform. The organic layer was washed with saturated brine and then dried over anhydrous sodium sulfate. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (10% to 100% ethyl acetate/hexane), and thus the title compound (66 mg) was obtained as a colorless solid.

Provenance & Evidence