HCID 71494339, compound → HCID 71494338, compound

Participants

Reaction Steps

A mixture of potassium 1-(benzyloxymethyl)cyclopropanesulfonate in SOCl2 (35 mL) and DMF (3.5 mL) was refluxed for 1.5 h and excess SOCl2 was removed under reduced pressure. Water was added carefully to the resulting mixture and extracted with ethyl acetate. The combined extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (5-10% ethyl acetate/hexanes) to obtain 1-(benzyloxymethyl)cyclopropanesulfonyl chloride 2 in 97% yields (3.3 g).

Provenance & Evidence