HCID 52951276, compound → HCID 52951277, compound

Participants

Reaction Steps

To a solution of 16 (0.17 g, 0.42 mmol) in 5 mL of EtOAc was added 10% palladium on carbon. The solution was filled with H2 and the reaction mixture was stirred for 2 hours. After the solution was filtered through Celite, the filtrate was concentrated in vacuo. Purification by column chromatography (3:7 EtOAc-hexanes) gave the title compound, 0.15 g (90%) as a white solid. mp 96.5-99.1° C. 1H NMR (300 MHz, DMSO-d6): δ 7.91 (d, J=9 Hz, 2H), 7.45 (d, J=9 Hz, 2H), 7.44-7.37 (m, 3H), 7.29-7.23 (m, 2H), 6.57 (s, 1H), 4.09 (q, J=7 Hz, 2H), 3.24 (s, 3H), 2.93 (t, J=7 Hz, 2H), 2.74 (t, J=7 Hz, 2H), 1.18 (t, J=7 Hz, 3H).

Provenance & Evidence