HCID 68819643, compound → HCID 86045712, compound

Participants

Reaction Steps

To a solution of alcohol 8c (0.46 g, 1.34 mmol) and 0.43 g of powdered 4 Å molecular sieves in 20 mL of DCM, was added PCC (0.43 g, 2.0 mmol) at room temperature. After 6 hours, the reaction mixture was filtered through a 0.75-in. pad of Celite. The filtrate was concentrated in vacuo then the residue was purified by column chromatography to afford the titled compound (0.21 g, 46%) as a white solid. mp 195.9-197.9° C. 1H NMR (300 MHz, DMSO-d6): δ 10.01 (s, 1H), 7.88 (d, J=9 Hz, 2H), 7.56 (d, J=9 Hz, 2H), 7.55-7.52 (m, 2H), 7.25-7.17 (m, 4H), 7.15 (s, 1H), 2.32 (s, 3H).

Provenance & Evidence