HCID 67976021, compound → HCID 67976211, compound

Participants

Reaction Steps

To a solution of 16c (0.13 g, 0.32 mmol) in 5 mL of EtOAc was added 10% palladium on carbon. The solution was filled with H2 and the reaction mixture was stirred for 2 hours. After the solution was filtered through Celite, the filtrate was concentrated in vacuo. Purification by column chromatography (3:7 EtOAc-haxanes) gave the title compound, 0.11 g (84%) as a white solid. mp 116.5-117.2° C. 1H NMR (300 MHz, CDCl3): δ 7.79 (d, J=9 Hz, 2H), 7.36 (d, J=9 Hz, 2H), 7.17-7.04 (m, 4H), 6.32 (s, 1H), 5.23 (s, 2H), 4.17 (q, J=7 Hz, 2H), 3.05 (t, J=8 Hz, 2H), 2.76 (t, J=8 Hz, 2H), 2.35 (s, 3H), 1.26 (t, J=7 Hz, 3H).

Provenance & Evidence