HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-((1-(2-(3-tert-butylureido)ethyl)piperidin-4-yl)methyl)-3,5-bis(trifluoromethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | tert-Butyl isocyanate | HCID 62412 | — |
| Reactant | N-((1-(2-aminoethyl)piperidin-4-yl)methyl)-3,5-bis(trifluoromethyl)benzamide | HCID 57993201 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-((1-(2-(3-tert-butylureido)ethyl)piperidin-4-yl)methyl)-3,5-bis(trifluoromethyl)benzamide | HCID 57993133 | — |
Reaction Steps
A solution of N-((1-(2-aminoethyl)piperidin-4-yl)methyl)-3,5-bis(trifluoromethyl)benzamide (25 mg, 0.063 mmol) in CH2Cl2 (1.5 mL) was treated with t-butyl isocyanate (30 mg, 0.13 mmol). The mixture was stirred overnight, treated with MeOH (1 mL). The solvent was removed in vacuo. The residue was purified by HiTOPs.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096522B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-bcbf395b56884623a90abc2fd5664150 |
| Source note | uspto-grants-2015_08 |