Hydrochloric Acid → HCID 71660814, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-(methylthio)-2-oxo-6-p-tolyl-2H-pyran-3-carboxylate (290 mg, 1 mmol), 2-phenyl-6,7-dihydro-2H-indazol-4(5H)-one (212 mg, 1 mmol) and powdered KOH (84 mg, 1.5 mmol) in dry DMF (5 mL) was stirred at 25° C. for 7 hr. At the end the reaction mixture was poured into ice water with vigorous stirring and finally neutralized with dilute HCl. The solid thus obtained was filtered and purified on a neutral alumina column using 15% chloroform in hexane as eluent to yield 334 mg (74%) of methyl 8-(methylthio)-2-phenyl-6-p-tolyl-4,5-dihydro-2H-benzo[e]indazole-9-carboxylate.

Provenance & Evidence