Oxalic Acid → (E)-2-Styryl-1-(4-trifloromethyl-2-Pyrimidyl)-1H-benzimidazole oxalate

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Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-Chloro-4-trifluromethyl-pyrimidine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound. MW: 411.37; mp: 189.0-191.0° C.; 1H-NMR (DMSO) δ: 9.42 (1H, d, J=4.8 Hz), 8.20-8.13 (1H, m), 8.10 (1H, dd, J=4.8, 1.3 Hz), 8.01 (1H, d, J=16.1 Hz), 7.91 (1H, d, J=16.1 Hz), 7.79-7.71 (1H, m), 7.68 (1H, d, J=7.0 Hz), 7.47-7.34 (6H, m).

Provenance & Evidence