HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-chloro-5-(N-cyclopropylsulfamoyl)benzoyl isocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-chloro-5-(N-cyclopropylsulfamoyl)benzamide | HCID 90020103 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 2-chloro-5-(N-cyclopropylsulfamoyl)benzoyl isocyanate | HCID 90019525 | 91.4% |
Reaction Steps
To a solution of 2-chloro-5-(N-cyclopropylsulfamoyl)benzamide (1.50 g, 5.46 mmol) in EDC (20 mL) was added oxalyl chloride (0.59 mL, 6.55 mmol). The reaction mass was refluxed for 1-2 h. Excess of solvent was removed under vacuum to afford 1.5 g of desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096545B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-25b576301cbe455f951fd6a7f21e5808 |
| Source note | uspto-grants-2015_08 |