HRID508794

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69045843

未命名化合物

2 次

结构：O=C=NC(=O)c1cc(S(=O)(=O)NC2CC2)ccc1Cl

HCID90019525

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(N(NC(=O)OC(C)(C)C)C(=O)NC(=O)c2cc(S(=O)(=O)NC3CC3)ccc2Cl)cc1OC

HCID90019382

未命名化合物

收率 16.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of tert-butyl 2-(3-methoxy-4-(methoxycarbonyl)phenyl)hydrazinecarboxylate (Intermediate 14, 1.5 g, 5.08 mmol) in DCM (20 mL) was added 2-chloro-5-(N-cyclopropylsulfamoyl)benzoyl isocyanate (1.6 g, 5.32 mmol). The reaction mass was stirred at RT for 2 h. Excess of solvent was removed under vacuum to afford 0.500 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 0.50 (m, 4H), 1.41 (s, 9H), 2.11 (m, 1H), 3.68-3.75 (m, 6H), 7.59 (d, J=8.7 Hz, 1H), 7.78-7.87 (m, 4H), 8.10 (m, 2H), 8.27 (s, 1H), 8.95 (s, 1H).

WORKUP

后处理

customExcess of solvent was removed under vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e849212cc27742b79678f676568327e1
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09096545B2
来源说明: uspto-grants-2015_08

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:13][NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH:6]=[CH:7][C:8]=1[C:9]([O:11][CH3:12])=[O:10].[Cl:22][C:23]1[CH:33]=[CH:32][C:31]([S:34](=[O:40])(=[O:39])[NH:35][CH:36]2[CH2:38][CH2:37]2)=[CH:30][C:24]=1[C:25]([N:27]=[C:28]=[O:29])=[O:26]>C(Cl)Cl>[Cl:22][C:23]1[CH:33]=[CH:32][C:31]([S:34](=[O:40])(=[O:39])[NH:35][CH:36]2[CH2:38][CH2:37]2)=[CH:30][C:24]=1[C:25]([NH:27][C:28]([N:13]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:3]([O:2][CH3:1])[CH:4]=1)[NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])=[O:29])=[O:26]