Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (E)-2-(2-Methylstyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | N1-(pyridin-2-yl)benzene-1,2-diamine | HCID 752150 | — |
| 반응물 | (e)-3-o-Tolylacryloyl chloride | HCID 5706558 | — |
| 반응물 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (E)-2-(2-Methylstyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride | HCID 22736767 | — |
반응 단계
Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and (E)-2-methylcinnamoyl chloride (Sekiya, T.; Hiranuma, H.; Hata, S.; Mizogami, S.; Hanazuka, M.; Yamada, S. J. Med. Chem., 1983, 26, 411) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethyl acetate/ethanol yielded the titled compound. MW: 347.85; mp: 212.0-215.0° C.; 1H-NMR (CDCl3) δ: 9.26 (1H, d, J=16.1 Hz), 8.89-8.83 (1H, m), 8.24-8.12 (2H, m), 7.72-7.64 (2H, m), 7.59-7.43 (4H, m), 7.43-7.11 (3H, m), 6.92 (1H, d, J=16.1 Hz), 2.70 (3H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713482B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-788d893663f043699acd01d7179b5f29 |
| 출처 메모 | uspto-grants-2004_03 |