Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → N-(4-chloro-5-(1-(4-chlorophenyl)-4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-2-fluorobenzyl)-2,2,2-trifluoroacetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | tert-Butyl 2-(4-chlorophenyl)hydrazinecarboxylate | HCID 59485730 | — |
| 반응물 | 5-((2,2,2-Tri fluoroacetamido)methyl)-2-chloro-4-fluorobenzoyl isocyanate | HCID 90018965 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(4-chloro-5-(1-(4-chlorophenyl)-4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-2-fluorobenzyl)-2,2,2-trifluoroacetamide | HCID 136492385 | 45.2% |
반응 단계
The title compound was prepared according to the procedure described in Example-83 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoyl isocyanate (Intermediate-69, 0.400 g), tert-butyl 2-(4-chlorophenyl)hydrazinecarboxylate (Intermediate-62, 0.400 g), DCM (20 mL) and trifluoro acetic acid (5.0 mL) to afford 0.250 g of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09096545B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-648b8b2a15194cb18f89e2840cce8206 |
| 출처 메모 | uspto-grants-2015_08 |