N1-(pyridin-2-yl)benzene-1,2-diamine → HCID 22736753, compound

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Reaction Steps

The titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and (E)-3-(2-furyl)acryloyl chloride (New, J. S.; Christopher, W. L.; Yevich, J. P.; Butler, R.; Schlemmer, R. F.; VanderMaelen, C. P.; Cipollina, J. A. J. Med. Chem., 1989, 32, 1147) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). MW: 287.32; mp: 164.0-165.0° C.; 1H-NMR (CDCl3) δ: 8.80-8.75 (1H, m), 8.00 (1H, ddd, J=7.7, 7.7, 1.8 Hz), 7.83-7.78 (1H, m), 7.78 (1H, d, J=15.4 Hz), 7.54-7.39 (4H, m), 7.37-7.16 (2H, m), 7.01 (1H, d, J=15.4 Hz), 6.51 (1H, d, J=3.3 Hz), 6.44 (1H, dd, J=3.3, 1.8 Hz).

Provenance & Evidence