1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 86731460, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-(4-(tert-butoxycarbonyl)piperazin-1-yl)isoquinoline-3-carboxylic acid (214 mg, 0.6 mmol), amine (65 mg, 0.6 mmol), HOAT (122 mg, 0.9 mmol), EDCI (229 mg, 1.2 mmol), and DIPEA (155 mg, 1.2 mmol) in DMF(5 mL) was stirred at 55° C. overnight. The mixture was quenched with water (20 mL) and extracted with EA(25 mL×2). The combined organic layers were separated, dried, filtered, and concentrated to a residue, which was purified by Pre-TLC to afford compound tert-butyl 4-(3-(2-aminophenylcarbamoyl)-isoquinolin-7-yl)piperazine-1-carboxylate (201 mg, 75%) as a yellow solid.

Provenance & Evidence