HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromopyruvate → Ethyl 6-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoxaline-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Reactant | Tert-butyl 4-(3,4-diaminophenyl)piperazine-1-carboxylate | HCID 18783789 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Ethyl 6-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoxaline-2-carboxylate | HCID 86731466 | 20% |
Reaction Steps
A mixture of tert-butyl-4-(3,4-diaminophenyl)piperazine-1-carboxylate (8 g, 27.6 mmol), Ethyl bromopyruvate (8 g, 41.4 mmol), and NMP (40 ml) was stirred at r.t. overnight. The solution was extracted by EA and purified by gel chromatography (PE:EA=3:1) to afford ethyl 6-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoxaline-2-carboxylate (2 g, yield: 20%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096549B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c3a40ebc8ff8411cae8280839e096308 |
| Source note | uspto-grants-2015_08 |