HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 6-(4-(Tert-butoxycarbonyl)piperazin-1-yl)quinoxaline-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 6-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoxaline-2-carboxylate | HCID 86731466 | — |
| Solvent | Tetrahydrofuran ethanol | HCID 21873804 | — |
| Product | 6-(4-(Tert-butoxycarbonyl)piperazin-1-yl)quinoxaline-2-carboxylic acid | HCID 86731467 | 56% |
Reaction Steps
To a solution of ethyl 6-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoxaline-2-carboxylate (500 mg, 1.3 mmol) in EtOH/THF (5 mL) was added NaOH (5 ml, 2 mmol) followed by stirring for 2 hrs at r.t. After extraction by EA, the combined organic layers were concentrated in vacuo to yield 6-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoxaline-2-carboxylic acid as a red solid (260 mg, yield: 56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096549B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-7b11e3ee00684471b064494369109763 |
| Source note | uspto-grants-2015_08 |