Hydrochloric Acid → 5-Chloro-2-fluoro-N-1,3,4-thiadiazol-2-yl-4-{[3-(trifluoromethyl)phenyl]thio}benzenesulfonamide

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Reaction Steps

To 5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-N-1,3,4-thiadiazol-2-yl-4-{[3-(trifluoromethyl)phenyl]thio}benzenesulfonamide (Preparation 3, 0.215 g, 0.347 mmol) was added a 4M solution of hydrogen chloride in 1,4-dioxane (5.04 mL). The reaction was stirred at ambient temperature for 5 hours before concentrating in vacuo. The residue was solubilised in dimethylsulfoxide (1 mL) and purified by the B-HPLC method to afford the title compound.

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