Hydrochloric Acid → HCID 56597619, compound

Participants

Reaction Steps

To 5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(4-methoxyphenyl)thio]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide (Preparation 4, 0.224 g, 0.387 mmol) in 1,4-dioxane (1 mL) was added a 4M solution of hydrogen chloride in 1,4-dioxane (3 mL). The reaction was stirred under a nitrogen atmosphere at ambient temperature overnight before concentrating in vacuo. The residue was purified by silica gel flash chromatography to afford a white solid. The solid was further purified by reverse phase column chromatography (Trilution system) to afford the title compound as a solid (0.115 g, 69%).

Provenance & Evidence