Hydrochloric Acid → HCID 56597620, compound

Participants

Reaction Steps

To 3-cyano-N-(2,4-dimethoxybenzyl)-4-[(3-methoxyphenyl)thio]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide (Preparation 17, 0.204 g, 0.368 mmol) was added a 4M solution of hydrogen chloride in 1,4-dioxane. The reaction was stirred at ambient temperature overnight. The reaction was quenched with methanol and passed through a plug of Arbocel™ to give a pale yellow solution. The solution was concentrated in vacuo to give a yellow solid. The solid was purified by silica gel flash column chromatography to give a white solid (0.141 g, 95%).

Provenance & Evidence