Hydrochloric Acid → HCID 56597924, compound

Participants

Reaction Steps

To 3-cyano-N-(2,4-dimethoxybenzyl)-4-[(2-fluorophenyl)thio]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide (Preparation 13, 0.320 g, 0.590 mmol) was added a 4M solution of hydrogen chloride in 1,4-dioxane (10 mL). The reaction was stirred at ambient temperature overnight before concentrating in vacuo. The residue purified by silica gel flash column chromatography (ethyl acetate:methanol elution) followed by reverse phase column chromatography to afford the title compound as a solid (0.055 g, 24%).

Provenance & Evidence