Trifluoroacetic acid → HCID 54765519, compound

Participants

Reaction Steps

4-{[2-(2-Aminopyridin-4-yl)-4-(trifluoromethyl)phenyl]thio}-5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide (Preparation 26, 0.153 g, 74.4 mmol) was dissolved in dichloromethane (3 mL). Trifluoroacetic acid (3 mL) was added and the mixture stirred at room temperature under nitrogen for 3 hours. Solvents were removed in vacuo and the residue diluted in ethyl acetate (10 mL) before washing with an aqueous solution of hydrochloric acid (10 mL, 2.0 M). The organic layer was collected, dried over sodium sulphate, filtered and concentrated in vacuo. The title compound was purified by trituration in a mixture of tert-butylmethylether and dichloromethane (2:1) to give the title compound as a white solid (0.021 g, 15%).

Provenance & Evidence