N1-(pyridin-2-yl)benzene-1,2-diamine → HCID 22736762, compound

Participants

Reaction Steps

The titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and (E)-3-(3-thienyl)acryloyl chloride (New, J. S.; Christopher, W. L.; Yevich, J. P.; Butler, R.; Schlemmer, R. F.; VanderMaelen, C. P.; Cipollina, J. A. J. Med. Chem, 1989, 32, 1147) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). MW: 303.39; mp: 135.5-136.0° C.; 1H-NMR (CDCl3) δ: 8.77 (1H, ddd, J=5.1, 1.8, 0.7 Hz), 8.03-7.95 (2H, m), 7.84-7.80 (1H, m), 7.54-7.43 (4H, m), 7.38-7.24 (4H, m), 6.97 (1H, d, J=15.7 Hz).

Provenance & Evidence