Potassium Carbonate → HCID 66652826, compound

Participants

Reaction Steps

5-Chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide (Preparation 2, 0.200 g, 0.433 mmol) and potassium carbonate (0.180 g, 1.30 mmol) were stirred in N,N-dimethylacetamide (1 mL). A solution of 4-methoxythiophenol (0.0576 g, 0.411 mmol) in N,N-dimethylacetamide (2 mL) was added dropwise to the reaction mixture and stirred at ambient temperature for 1 hour. The reaction was quenched with a 1M aqueous solution of sodium hydroxide whereupon a precipitate formed. The precipitate was collect by filtration to afford the title compound (0.224 g, 89%) and this was used in the next step without purification.

Provenance & Evidence