Potassium Carbonate → HCID 86682480, compound

Participants

Reaction Steps

2-Methoxythiophenol (0.0322 g, 0.230 mmol) and potassium carbonate (0.158 g, 1.14 mmol) were stirred in N,N-dimethylacetamide. 3-Cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide (Preparation 1, 0.248 g, 0.571 mmol) was added to the reaction mixture portion-wise and the mixture stirred under a nitrogen atmosphere at ambient temperature for 2 hours. The reaction was quenched with a 1M aqueous solution of sodium hydroxide (100 mL) and extracted with ethyl acetate (3×100 mL). The organic layer was separated and washed with water (100 mL), dried over MgSO4, filtered and concentrated in vacuo to give a yellow oil. The oil was purified by silica gel column chromatography (ethyl acetate elution) to afford the title compound (0.295 g, 93%) and this was used without further purification.

Provenance & Evidence