Potassium Carbonate → HCID 86682481, compound

Participants

Reaction Steps

3-Cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide (Preparation 1, 0.100 g, 0.230 mmol) and potassium carbonate (0.0668 g, 0.483 mmol) were stirred in N,N-dimethylacetamide (3 mL). 4-Methoxythiophenol (0.0322 g, 0.230 mmol) was added to the reaction mixture and stirred under a nitrogen atmosphere at ambient temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was separated and washed with a 1M aqueous solution of sodium hydroxide, then brine (×3). The organic layer was dried, filtered and concentrated in vacuo to afford the title compound as a solid (0.13 g, 100%), which was used without purification.

Provenance & Evidence