Potassium Carbonate → HCID 66652799, compound

Participants

Reaction Conditions

Reaction Steps

3-Methoxythiophenol (0.0801 g, 0.571 mmol) and potassium carbonate (0.158 g, 1.14 mmol) were stirred in dimethylsulphoxide. 3-Cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide (Preparation 1, 0.248 g, 0.571 mmol) was added to the reaction mixture and the mixture stirred at 50° C. overnight. The reaction mixture was partitioned between ethyl acetate and water. A 1M aqueous solution of sodium hydroxide was added to the mixture. The organic layer was separated and dried over MgSO4, filtered and concentrated in vacuo to afford a white solid. The solid was triturated in ethyl acetate and filtered to afford the title compound (0.204 g, 64%).

Provenance & Evidence