反应详情

To a solution of 4-[1-(tetrahydro-pyran-4-yl)-meth-(E)-ylidene]-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione (270 mg, 0.86 mmol) in ethanol (10 ml) was added 10% palladium on charcoal (27 mg) and the resulting solution stirred under hydrogen (3 bar) for 5 hours at room temperature. The reaction mixture was then filtered through a pad of celite, which was washed with methanol, and the filtrated concentrated in vacuuo to give 4-(tetrahydro-pyran-4-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione (258 mg).

1. filtrationThe reaction mixture was then filtered through a pad of celite, which
2. washwas washed with methanol
3. concentrationthe filtrated concentrated in vacuuo