Phenylacetylene → HCID 57779447, compound

Participants

Reaction Steps

To a solution of ethyl 2-bromo-2-phenylacetate 21 (1.60 g, 6.58 mmol) in sodium azide/DMSO solution (0.5 M, 13.16 mL, 6.58 mmol) which had been stirred at room temperature for 1 h was added water (10 mL), sodium ascorbate (0.130 g, 0.658 mmol), phenylacetylene (0.723 mL, 6.58 mmol) and aq. copper(II) sulfate solution (1.0 M, 1.30 mL, 1.30 mmol) (in that order). The reaction mixture was stirred for 16 h. Brine was added and extraction with ethyl acetate. The organic layer was dried over Na2SO4, filtered, and concentrated. The crude material was purified by silica gel column chromatography with gradient of ethyl acetate (0-50%) in hexane to afford compound (24) as a light yellow solid (1.31 g, 65%). LRMS: calc. 307.4, found 308.4 (MH)+.

Provenance & Evidence