Methanol → Methyl 2-(4-bromophenyl)-2-phenylacetate

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	Sulfuric Acid	HCID 1118	—
Reactant	4-Bromo-alpha-phenylbenzeneacetic acid	HCID 3847307	—
Product	Methyl 2-(4-bromophenyl)-2-phenylacetate	HCID 57779541	85%

Reaction Conditions

Temperature	60 °C

Reaction Steps

A solution of acid 53 (1.9 g, 6.53 mmol) in methanol (20 mL) was added concentrated sulfuric acid (2 mL) and the reaction mixture was stirred at 60° C. for 4 h. The organic layer was separated, dried over Na2SO4, filtered and concentrated to afford methyl 2-(4-bromophenyl)-2-phenylacetate 54 (1.7 g, 85% yield) as a brown oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09096565B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-047f44371fa74e5c82811dd3dffc762e
Source note	uspto-grants-2015_08