HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-nitroaniline → (E)-5-Fluoro-1-(2-pyridyl)-2-styryl-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-nitroaniline | HCID 67769 | — |
| Reactant | (E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole | HCID 22736704 | — |
| Product | (E)-5-Fluoro-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 22736771 | — |
Reaction Steps
The titled compound was prepared from 4-fluoro-2-nitroaniline according to the preparation of (E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole (Example 57). MW: 315.35; mp: 134.0-135.0° C.; 1H-NMR (CDCl3) δ: 8.78 (1H, ddd, J=4.8, 1.8, 1.1 Hz), 8.04-7.96 (1H, m), 8.00 (1H, d, J=15.8 Hz), 7.54-7.45 (5H, m), 7.42-7.30 (4H, m), 7.10 (1H, d, J=16.1 Hz), 7.01 (1H, td, J=9.2, 2.6 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713482B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-46e25139ab334712ae031c4c25160f25 |
| Source note | uspto-grants-2004_03 |