Ammonium Chloride → HCID 57779686, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of compound 83 (1.05 g, 3.20 mmol) and ammonium chloride (2.67 g, 49.8 mmol) in ethanol (35 mL) was added zinc (2.67 g, 40.8 mmol) and the reaction mixture was heated at 80° C. for 30 minutes then filtered through a pad of Celite®. The solution was diluted with brine, extracted with EtOAc, and the combined organics were dried over, filtered and concentrated to afford compound 84 (0.248 g, 24%) as a white solid after purification by flash chromatography (10 to 40% EtOAc in hexanes). LRMS (ESI): (calc) 329.39 (found) 330.5 (MH)+

Provenance & Evidence