HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 4-(2-(Dimethylamino)-2-(thiophen-3-yl)acetamido)-2-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-Amino-2-methylbenzamide | HCID 23068206 | — |
| Reactant | 2-(Dimethylamino)-2-(thiophen-3-yl)acetic acid | HCID 43803170 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-(2-(Dimethylamino)-2-(thiophen-3-yl)acetamido)-2-methylbenzamide | HCID 59161736 | — |
Reaction Steps
To 2-(dimethylamino)-2-(thiophen-3-yl)acetic acid in pyridine was added EDC, DMAP and 4-amino-2-methylbenzamide (E112) and the solution was stirred for 10 hours at room temperature. The mixture was poured into NaHCO3 (sat) and extracted with EtOAc. The extracts were dried (MgSO4), filtered and evaporated. Column chromatography (SiO2, 0-100% EtOAc/Hex) gave pure 4-(2-(dimethylamino)-2-(thiophen-3-yl)acetamido)-2-methylbenzamide (E113).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096569B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5bda8d283f1442c7a18001098f37e5fb |
| Source note | uspto-grants-2015_08 |