HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → Methyl 4-(2-(dimethylamino)-2-(thiophen-3-yl)acetamido)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 4-Aminobenzoate | HCID 4876 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-(Dimethylamino)-2-(thiophen-3-yl)acetic acid | HCID 43803170 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Methyl 4-(2-(dimethylamino)-2-(thiophen-3-yl)acetamido)benzoate | HCID 59161754 | — |
Reaction Steps
To 2-(dimethylamino)-2-(thiophen-3-yl)acetic acid in pyridine was added EDC, DMAP and 4-aminobenzoate and the solution was stirred for 10 hours at room temperature. The mixture was poured into NaHCO3 (sat) and extracted with EtOAc. The extracts were dried (MgSO4), filtered and evaporated. Column chromatography (SiO2, 0-100% EtOAc/Hex) gave pure methyl 4-(2-(dimethylamino)-2-(thiophen-3-yl)acetamido)benzoate (E114).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096569B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c2244893f0df46c887672e1ed01468aa |
| Source note | uspto-grants-2015_08 |