HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 509241Generated: October 30, 2026
Formamide → 4-(2-(Dimethylamino)-2-(thiophen-3-yl)acetamido)benzamide
https://huagongshe.com/reaction/509241
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Methyl 4-(2-(dimethylamino)-2-(thiophen-3-yl)acetamido)benzoate | HCID 59161754 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(2-(Dimethylamino)-2-(thiophen-3-yl)acetamido)benzamide | HCID 46184604 | — |
Reaction Steps
Methyl 4-(2-(dimethylamino)-2-(thiophen-3-yl)acetamido)benzoate (E114) and formamide dissolved in DMF under Ar were heated to 100° C. The NaOMe was then added and the reaction heated for 2 hours. The reaction was partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc. The extracts were dried (MgSO4), filtered and evaporated. Column chromatography (SiO2, 0-100% EtOAc/Hex) gave pure 4-(2-(dimethylamino)-2-(thiophen-3-yl)acetamido)benzamide (E115).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09096569B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-106b258c557e4dbc9e0fccd8823e24d4 |
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| Source note | uspto-grants-2015_08 |
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