Hydrochloric Acid → HCID 54591670, compound

Participants

Reaction Steps

Methyl 3-(4-(6-(adamantan-2-ylcarbamoyl)pyridin-2-yl)piperazin-1-yl)propanoate (43 mg, 0.101 mmol) was added into 4N aqueous HCl solution (2 ml), and heated at reflux for 2 hours. The resulting reaction liquid was concentrated under reduced pressure, and then neutralized by slow addition of a saturated aqueous NaHCO3 solution, followed by extraction with a mixture solution (10 ml×2) of THF:MC=4:1. The organic layer was dried over anhydrous magnesium sulfate, followed by filtration and concentration, and then the residue thus obtained was subjected to MPLC (10% MeOH/MC), to obtain 27 mg of pale yellow oil (65%). MS (ESI): 413 [M+H]+

Provenance & Evidence