反应详情

Tert-butyl 4-(5-chloropyridin-2-yl)piperazine-1-carboxylate (170 mg, 0.571 mmol) was dissolved in MC (3 ml), followed by addition of trifluoroacetic acid (3 ml), and then the resulting mixture was stirred at room temperature for 2 hours. The resulting reaction liquid was concentrated under reduced pressure, followed by addition of a saturated aqueous NaHCO3 solution (15 ml), and extracted with MC (15 ml×3). The organic layer was dried over anhydrous sodium sulfate, followed by filtration, concentration, and vacuum drying, to obtain 112 mg of white solid (99%).

1. customThe resulting reaction liquid
2. concentrationwas concentrated under reduced pressure
3. additionfollowed by addition of a saturated aqueous NaHCO3 solution (15 ml)
4. extractionextracted with MC (15 ml×3)
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. filtrationfollowed by filtration, concentration, and vacuum
7. customdrying