Oxalic Acid → (E)-1-(2-Pyridyl)-2-styryl-5-methoxy-1H-benzimidazole oxalate

関与物質

反応手順

Free base of the titled compound was prepared from 4-methoxy-2-nitroaniline according to the preparation of (E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole (Example 57). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound. MW: 417.42; mp: 187.0-188.0° C.; 1H-NMR (DMSO-d6) δ: 8.76 (1H, dd, J=5.0, 1.3 Hz), 8.17 (1H, td, J=7.8,2.0 Hz), 7.85 (1H, d, J=15.8 Hz), 7.72 (1H, d, J=8.1 Hz), 7.65-7.58 (3H, m), 7.42-7.30 (4H, m), 7.26 (1H, d, J=2.2 Hz), 7.17 (1H, d, J=16.1 Hz), 6.90 (1H, dd, J=8.8, 2.6 Hz), 3.83 (3H, s).

情報源と証拠