Tetrahydrofuran → 2-Oxo-1,2,4a,8a-tetrahydroquinoline-6-carboxylic Acid

Participants

Reaction Steps

A solution of methyl 2-chloroquinoline-6-carboxylate (60 mg, 0.271 mmol) in THF/5 N aqueous HCl (1:1, 2 mL) was heated to 60° C. in a heating block. LCMS shows major product 86% peak area corresponding to title compound with hydrolysis of methyl ester (m/z=189.9). The reaction was concentrated and used in the subsequent amide coupling steps without further purification.

Provenance & Evidence