HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole → (E)-5-Fluoro-2-[2-(3-furyl)ethenyl]-1-(2-pyridyl)-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Reactant | 4-fluoro-2-amino-N-(2-pyridyl)aniline | HCID 22736745 | — |
| Reactant | 3-Cyclohexylprop-2-enoyl chloride | HCID 56623207 | — |
| Product | (E)-5-Fluoro-2-[2-(3-furyl)ethenyl]-1-(2-pyridyl)-1H-benzimidazole | HCID 22736678 | — |
Reaction Steps
The titled compound was prepared from 4-fluoro-2-amino-N-(2-pyridyl)aniline and (E)-3-(3-Cyclohexylacryloyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). MW: 305.31; mp: 168.0-170.0° C.; 1H-NMR (CDCl3) δ: 8.82-8.76 (1H, m), 8.15 (1H, d, J=16.0 Hz), 8.04 (1H, ddd, J=7.7, 7.7, 1.8 Hz), 7.71 (1H, s), 7.60-7.50 (3H, m), 7.43-7.33 (2H, m), 7.05 (1H, ddd, J=9.1, 9.1, 2.5 Hz), 6.74 (1H, d, J=16.0 Hz), 6.53 (1H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713482B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-74bf31554aca427f83f8aeec0e68dc79 |
| Source note | uspto-grants-2004_03 |