Sodium Methoxide → HCID 72188185, compound

HRID 509444Notes

Reaction equation

HRID 509444 reaction equation
S([C:5]1[CH:11]=[CH:10][C:8](C)=[CH:7][CH:6]=1)(O)(=O)=O.[CH3:12][N:13]([CH3:30])[C:14]([C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][C:21]([NH:25][C:26]([NH2:28])=[NH:27])=[CH:20][C:19]=2[CH3:29])=[O:15].C[O-].[Na+]>CO>[CH3:12][N:13]([CH3:30])[C:14]([C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][C:21]([NH:25][C:26]1[N:28]=[C:7]([C:8]3[N:27]=[CH:26][N:25]([CH3:21])[C:10]=3[CH3:11])[CH:6]=[CH:5][N:27]=1)=[CH:20][C:19]=2[CH3:29])=[O:15]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 178428588HCID 178428588, compound

Product 1

HCID 72188185HCID 72188185, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 42.5 mg 4.5, 80.0 mg 7.7 and 10.8 mg sodium methylate in 2 ml methanol was stirred at 140° C. for 60 min under microwave irradiation. The resulting mixture was purified by preparative HPLC. The combined product fractions were evaporated. The residue was dissolved in acetonitrile/water 1/1 and lyophilized to obtain the Example 1.

Workup

  1. customThe resulting mixture was purified by preparative HPLC
  2. customThe combined product fractions were evaporated
  3. dissolutionThe residue was dissolved in acetonitrile/water 1/1
  4. customto obtain the Example 1

Sources & evidence

ORD record
ord-f9ee2d9d7506424fb3d7d76383b5fd64
Source dataset
uspto-grants-2015_08
Patent number
US09096579B2

Reaction notes

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