反应详情

8.1 g (0.15 mol) of sodium methoxide was added to a dried single-neck flask equipped with constant pressure dropping funnel and drying pipe. The flask was cooled with ice bath for 10 min. 50 ml of absolute ethanol was added and the mixture was stirred. 10.857 g (0.1 mol) of propanimidamide monohydrochloride was charged into the flask after the sodium methoxide was dissolved, resulting a suspension. Then 16.9 g (0.1 mol) of ethyl cyano(ethoxymethylene)acetate in 70 ml of absolute ethanol was dropped into the flask through the dropping funnel. The reaction turned to yellow from white. The reaction was stirred for 1-2 h after the addition was finished. Ice water was poured into the flask. Precipitate formed was filtered and washed twice with water. 12 g of ethyl 4-amino-2-ethylpyrimidine-5-carboxylate was obtained (yield 62%) after drying.

1. customequipped with constant pressure
2. customdrying pipe
3. temperatureThe flask was cooled with ice bath for 10 min
4. addition50 ml of absolute ethanol was added
5. dissolutionwas dissolved
6. customresulting a suspension
7. stirringThe reaction was stirred for 1-2 h
8. additionafter the addition
9. customPrecipitate formed
10. filtrationwas filtered
11. washwashed twice with water