HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 118060526, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Amino-2-ethyl-5-pyrimidinemethanol | HCID 20268149 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 118060526 | HCID 118060526 | — |
Reaction Steps
4.59 g (0.03 mol) of 4-amino-2-ethyl-5-(hydroxymethyl)-pyrimidine was charged into a 100 ml flask, followed by 20 ml of dichloromethane, 20 ml of toluene and 0.1 ml of pyridine. 6.5 ml of thionyl chloride (0.28 mol) was dropped in slowly with cooling by ice bath. Then the reaction was stirred overnight. Solvent was removed and the residue was used for next step directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096581B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c3b73ad826fd4c429b62abe2db003646 |
| Source note | uspto-grants-2015_08 |