Dimethyl Sulfoxide → HCID 131733249, compound

Participants

Reaction Conditions

Reaction Steps

To 25 ml flask 1.7 g (8.2 mmol) of 4-amino-5-chloromethyl 2-ethylpyrimidine hydrochloride and 1.3 g (9.0 mmol) of 5-(2-fluoroethyl)-4-methylthiazole were charged, followed by 1 ml of DMSO. The reaction mixture was stirred at 100° C. for 20 minutes. Then it was cooled to room temperature and 10 ml of isopropanol was added. After standing for 2 h, a precipitate was formed and filtered. 2 g of 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-fluoroethyl)-4-methylthiazol chloride hydrochloride was obtained as white solid (yield 70%).

Provenance & Evidence