Formic Acid → HCID 89543743, compound

Participants

Reaction Steps

To formic acid (6.24 g, 135.6 mmol) was added dropwise 3.96 g (38.8 mmol) of acetic anhydride (exothermic, cooling with tap water was used). The reaction mixture was stirred for 1 hr. The resulting mixture was transferred via cannula into another reaction flask containing a solution of 3-(4-amino-3-methoxyphenyl)-5,6-dihydrobenzo[d]isoxazol-7(4H)-one in 50 ml of THF (Cooling with tap water was used). The mixture was stirred for 2 hr, extracted with DCM, washed with water and brine, dried over sodium sulfate and concentrated to furnish 2.65 g of the title compound, MS(M+H)+=287.

Provenance & Evidence