Sodium Hydroxide → HCID 67481594, compound

Participants

Reaction Conditions

Reaction Steps

Polyphosphonic acid (4.006 mL of 84% w/v, 41.04 mmol) was heated to 100° C. and treated with 2-amino-N′-benzoyl-5-bromonicotinohydrazide (673 mg, 1.626 mmol) in portions over a period of 25 minutes. The reaction mixture was allowed to stir for 2 hours at 110° C. and then allowed to cool to ambient temperature. Water was added and the mixture basified (using 1M NaOH) and extracted with DCM (×3). The organic layer was separated, washed with brine, dried (MgSO4), filtered and concentrated in vacuo to give the product as a white solid (372 mg, 72% Yield). 1H NMR (400.0 MHz, DMSO) δ 7.54 (s, 2H), 7.62-7.68 (m, 3H), 8.22-8.25 (m, 2H), 8.32 (d, J=2.5 Hz, 1H) and 8.50 (d, J=2.5 Hz, 1H) ppm; MS (ES+) 318.86.

Provenance & Evidence